Efficacy of treatments used to relieve signs and symptoms associated with teething: a systematic review

Abstract: The purpose of this review was to systematically evaluate all the existing literature on the efficacy of treatments used to relieve the signs and symptoms associated with teething. A systematic search up to February 2021, without restrictions on language or date of publication, was carried out in MEDLINE/PubMed, SCOPUS, Web of Science, The Cochrane Library, EMBASE, LILACS, BBO, OpenGrey, Google Scholar, Portal de Periódicos da CAPES, clinicaltrials.gov, and the references of the included studies. Clinical studies that evaluated the effect of any intervention to alleviate the signs and symptoms associated with teething in babies and children were included. The risk of bias was assessed using the ROB-2 and ROBINS-I tools. The characteristics and results of the individual studies were extracted and synthesized narratively. The GRADE approach was followed to rate the certainty of the evidence. Three randomized and two non-randomized clinical trials were included. The outcomes of these five articles were classified as high or serious risk of bias. Three studies using homeopathy reported improvement in appetite disorders, gum discomfort, and excess salivation. One study showed a new gel with hyaluronic acid was more effective than an anesthetic gel in improving signs and symptoms such as pain, gingival redness, and poor sleep quality. Another study applied non-pharmacological treatments, which were more effective, especially against excess salivation. Although the present systematic review suggests some therapies could have a favorable effect on signs and symptoms related to teething, definitive conclusions on their efficacy cannot be drawn because of the very low certainty of the evidence. The existing literature on the subject is scarce and heterogeneous and has methodological flaws; therefore, further high-quality investigations are necessary.

Replantation of avulsed tooth: a step-by-step report

Introduction: Avulsion is a serious injury that causes damage to dental and supportive tissues, and is characterized by complete displacement of a tooth from its socket. In most situations, replantation is the treatment of choice for permanent tooth avulsion, and appropriate management is critical for a good prognosis in these cases. Previous studies have shown that the level of knowledge of dentists regarding the management of an avulsed tooth is deficient and have underscored the importance of continuing dental education to further the knowledge of general dentists in the urgency management of permanent avulsed teeth. Objective: This report aims to present a step-by-step clinical sequence involving the reimplantation of a mature permanent tooth that suffered avulsion,following the CARE guide. Case report: Tooth 21, stored in milk, was reimplanted 2 hours after avulsion and stabilized with flexible containment. The clinical steps were carried out according to the recommendations of the International Association of Dental Traumatology. Endodontic treatment was started five days after reimplantation, with periodic changes of intracanal medication. The patientis currently under follow-up, with no negative signs or symptoms related to avulsion. Conclusion: Dental reimplantation after avulsion should be performed after a thorough systemic and oral diagnosis and tooth storage conditions, with a clinical protocol based on scientific evidence of associations of dentoalveolar trauma.

Introdução: A avulsão é uma injuria grave que causa sérios danos aos tecidos de suporte do doente e é caracterizada pelo completo deslocamento do elemento dentário de dentro do alvéolo. O reimplante é, na maioria das situações, o tratamento de escolha para o dente permanente avulsionado e uma conduta correta é necessária para um bom prognostico nestes casos. Estudos prévios mostram que o conhecimento de dentistas sobre o manejo de um dente que sofreu avulsão é deficiente e destacam a importância da educação continuada, com a intenção de aumentar o nível de conhecimento de dentistas clínicos frente a urgências envolvendo dentes avulsionados. Objetivo: este relato tem como objetivo apresentar uma sequência clínica passo-a-passo envolvendo o reimplante de um dente permanente maduro que sofreu avulsão, seguindo o guia CARE. Relato do caso: O dente 21, armazenado em leite, foi reimplantado 2 horas após a avulsão e estabilizado com contenção flexível. As etapas clínicas foram realizadas conforme as recomendações da Associação Internacional de Traumatismos Dentários. O tratamento endodôntico foi iniciado cinco dias após o reimplante, com trocas periódicas de medicação intracanal. Atualmente o paciente encontra-se em acompanhamento, sem sinais ou sintomas negativos relacionados a avulsão. Conclusão: O reimplante dental após avulsão deve ser realizado após minucioso diagnóstico e condições de armazenamento do dente, com protocolo clínico embasado nas evidências científicas das associações de traumatismos dentoalveolares.